Don’t be cavalier about tylenol– just a little too much can have dire effects including liver failure

I recently listened to an eye-opening podcast from This American Life which details that on average 150 people die each year from unintentional tylenol toxicity. Many others end up with organ failure often resulting in transplantation. You can read the transcript or listen to the podcast . Who among us hasn’t once taken a few more tylenol than recommended? I for one am guilty but never again after learning that just a small amount of acetaminophen over the recommended dosage can set off a cascade of health events.  As a medical librarian, I also did research on Pubmed ( the major database of medical literature) and here is a selected list of 21 recent articles on the topic of acetaminophen toxicity and liver failure.

Selected , recent  English language articles on liver failure and acetaminophen (tylenol)

1. Leonis MA, Alonso EM, Im K, Belle SH, Squires RH; Pediatric Acute Liver

Failure Study Group. Chronic acetaminophen exposure in pediatric acute liver

failure. Pediatrics. 2013 Mar;131(3):e740-6. doi: 10.1542/peds.2011-3035. Epub

2013 Feb 25. PubMed PMID: 23439908; PubMed Central PMCID: PMC3581836.

 

2, Court MH, Freytsis M, Wang X, Peter I, Guillemette C, Hazarika S, Duan SX,
Greenblatt DJ, Lee WM; Acute Liver Failure Study Group. The
UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is
associated with increased human liver acetaminophen glucuronidation, increased
UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional
acetaminophen-induced acute liver failure. J Pharmacol Exp Ther. 2013
May;345(2):297-307. doi: 10.1124/jpet.112.202010. Epub 2013 Feb 13. PubMed PMID: 
23408116; PubMed Central PMCID: PMC3629801.

 

3. Gulmez SE, Larrey D, Pageaux GP, Lignot S, Lassalle R, Jové J, Gatta A,
McCormick PA, Metselaar HJ, Monteiro E, Thorburn D, Bernal W, Zouboulis-Vafiadis 
I, de Vries C, Perez-Gutthann S, Sturkenboom M, Bénichou J, Montastruc JL,
Horsmans Y, Salvo F, Hamoud F, Micon S, Droz-Perroteau C, Blin P, Moore N.
Transplantation for acute liver failure in patients exposed to NSAIDs or
paracetamol (acetaminophen): the multinational case-population SALT study. Drug
Saf. 2013 Feb;36(2):135-44. doi: 10.1007/s40264-012-0013-7. PubMed PMID:
23325533; PubMed Central PMCID: PMC3568201.

4. Craig DG, Zafar S, Reid TW, Martin KG, Davidson JS, Hayes PC, Simpson KJ. The
sequential organ failure assessment (SOFA) score is an effective triage marker
following staggered paracetamol (acetaminophen) overdose. Aliment Pharmacol Ther.
2012 Jun;35(12):1408-15. doi: 10.1111/j.1365-2036.2012.05102.x. Epub 2012 Apr 23.
PubMed PMID: 22524320.

 

5. Craig DG, Zafar S, Reid TW, Martin KG, Davidson JS, Hayes PC, Simpson KJ. The
sequential organ failure assessment (SOFA) score is an effective triage marker
following staggered paracetamol (acetaminophen) overdose. Aliment Pharmacol Ther.
2012 Jun;35(12):1408-15. doi: 10.1111/j.1365-2036.2012.05102.x. Epub 2012 Apr 23.
PubMed PMID: 22524320.

 

6. Craig DG, Reid TW, Wright EC, Martin KG, Davidson JS, Hayes PC, Simpson KJ.
The sequential organ failure assessment (SOFA) score is prognostically superior
to the model for end-stage liver disease (MELD) and MELD variants following
paracetamol (acetaminophen) overdose. Aliment Pharmacol Ther. 2012
Mar;35(6):705-13. doi: 10.1111/j.1365-2036.2012.04996.x. Epub 2012 Jan 20. PubMed
PMID: 22260637.

 

7. Audimoolam VK, Wendon J, Bernal W, Heaton N, O'Grady J, Auzinger G. Iron and 
acetaminophen a fatal combination? Transpl Int. 2011 Oct;24(10):e85-8. doi:
10.1111/j.1432-2277.2011.01322.x. Epub 2011 Aug 30. PubMed PMID: 21883506.

 

8. Sabaté M, Ibáñez L, Pérez E, Vidal X, Buti M, Xiol X, Mas A, Guarner C, Forné
M, Solà R, Castellote J, Rigau J, Laporte JR. Paracetamol in therapeutic dosages 
and acute liver injury: causality assessment in a prospective case series. BMC
Gastroenterol. 2011 Jul 15;11:80. doi: 10.1186/1471-230X-11-80. PubMed PMID:

21762481; PubMed Central PMCID: PMC3150324.

9. Sabaté M, Ibáñez L, Pérez E, Vidal X, Buti M, Xiol X, Mas A, Guarner C, Forné
M, Solà R, Castellote J, Rigau J, Laporte JR. Paracetamol in therapeutic dosages 
and acute liver injury: causality assessment in a prospective case series. BMC
Gastroenterol. 2011 Jul 15;11:80. doi: 10.1186/1471-230X-11-80. PubMed PMID:

21762481; PubMed Central PMCID: PMC3150324.

10, Ceelie I, James LP, Gijsen V, Mathot RA, Ito S, Tesselaar CD, Tibboel D,
Koren G, de Wildt SN. Acute liver failure after recommended doses of
acetaminophen in patients with myopathies. Crit Care Med. 2011 Apr;39(4):678-82. 
doi: 10.1097/CCM.0b013e318206cc8f. PubMed PMID: 21242792; PubMed Central PMCID:
PMC3209512.

 

11. Lavonas EJ, Reynolds KM, Dart RC. Therapeutic acetaminophen is not associated
with liver injury in children: a systematic review. Pediatrics. 2010
Dec;126(6):e1430-44. doi: 10.1542/peds.2009-3352. Epub 2010 Nov 22. Review.
PubMed PMID: 21098156.

12. Jepsen P, Schmidt LE, Larsen FS, Vilstrup H. Long-term prognosis for
transplant-free survivors of paracetamol-induced acute liver failure. Aliment
Pharmacol Ther. 2010 Oct;32(7):894-900. doi: 10.1111/j.1365-2036.2010.04419.x.
PubMed PMID: 20735774.
13. Karvellas CJ, Safinia N, Auzinger G, Heaton N, Muiesan P, O'Grady J, Wendon
J, Bernal W. Medical and psychiatric outcomes for patients transplanted for
acetaminophen-induced acute liver failure: a case-control study. Liver Int. 2010 
Jul;30(6):826-33. doi: 10.1111/j.1478-3231.2010.02243.x. Epub 2010 Apr 8. PubMed 
PMID: 20408947.

 

14. Mehrpour O, Shadnia S, Sanaei-Zadeh H. Late extensive intravenous
administration of N-acetylcysteine can reverse hepatic failure in acetaminophen
overdose. Hum Exp Toxicol. 2011 Jan;30(1):51-4. doi: 10.1177/0960327110366182.
Epub 2010 Mar 23. PubMed PMID: 20332167.

 

15. Khan LR, Oniscu GC, Powell JJ. Long-term outcome following liver
transplantation for paracetamol overdose. Transpl Int. 2010 May 1;23(5):524-9.
doi: 10.1111/j.1432-2277.2009.01007.x. Epub 2009 Nov 25. PubMed PMID: 20002359.

 

16. Cooper SC, Aldridge RC, Shah T, Webb K, Nightingale P, Paris S, Gunson BK,
Mutimer DJ, Neuberger JM. Outcomes of liver transplantation for paracetamol
(acetaminophen)-induced hepatic failure. Liver Transpl. 2009 Oct;15(10):1351-7.
doi: 10.1002/lt.21799. PubMed PMID: 19790165.

 

17. Simpson KJ, Bates CM, Henderson NC, Wigmore SJ, Garden OJ, Lee A, Pollok A, 
Masterton G, Hayes PC. The utilization of liver transplantation in the management
of acute liver failure: comparison between acetaminophen and non-acetaminophen
etiologies. Liver Transpl. 2009 Jun;15(6):600-9. doi: 10.1002/lt.21681. PubMed
PMID: 19479803.

18. 125: Gentili A, Latrofa ME, Giuntoli L, Melchionda F, Pession A, Lima M,
Baroncini S. Acute liver failure associated with a prolonged course of
acetaminophen at recommended dosages in paediatric age. Pediatr Med Chir. 2008
Nov-Dec;30(6):302-5. PubMed PMID: 19431953.

19. Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang
H, Rochon J; Drug Induced Liver Injury Network (DILIN). Causes, clinical
features, and outcomes from a prospective study of drug-induced liver injury in
the United States. Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4. doi:
10.1053/j.gastro.2008.09.011. Epub 2008 Sep 17. PubMed PMID: 18955056; PubMed
Central PMCID: PMC3654244.

 

20. Fontana RJ. Acute liver failure including acetaminophen overdose. Med Clin
North Am. 2008 Jul;92(4):761-94, viii. doi: 10.1016/j.mcna.2008.03.005. Review.

PubMed PMID: 18570942; PubMed Central PMCID: PMC2504411

21. Dart RC, Bailey E. Does therapeutic use of acetaminophen cause acute liver

failure? Pharmacotherapy. 2007 Sep;27(9):1219-30. Review. PubMed PMID: 17723075

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Filed under Acetaminophen toxicity, Liver failure

UNOS document: Questions and Answers for Transplant Candidates about Liver Allocation Policy

unos UNOS (the Network for Organ Sharing) operates the Organ Procurement and Transplantation Network (OPTN) under federal contract.  As part of this process, the OPTN/UNOS developed a system that prioritizes liver transplant candidates. This six page document, Questions & Answers for Transplant Candidates about Liver Allocation Policy explains what the MELD and PELD scores are, how they will be utilized, how livers are allocated and information about the little known concept of applying for an exception if the transplant team feels that a candidate’s medical conditions are not fully covered by the MELD or PELD scores. This document is written in plain English and should be required reading for everyone waiting for a liver transplant.

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Filed under Liver Transplantation, Organ Allocation

Have you heard of CaringBridge?

CaringBridge is a unique online space that you can use to keep family and friends up to date about your transplant news– or for that matter, news about any type of health event that you may be experiencing. Tired of having to email all your contacts every night about the latest  developments in your health journey? There is an easy solution– create a personal, protected online space where you can connect, share news and receive support. Not only is it free, but it’s easy. Once created, your friends and family can log into your personal website and not only receive your current news, but they can also send you messages of support and caring. Another unique feature of CaringBridge is its’ Support Planner tools. This is a calendar that family and friends can use to coordinate care and helpful tasks such as signing up to bring a meal, doing a grocery run, etc.

CaringBridge is a nonprofit entity and offers protected online spaces with an array of privacy settings. In just a few minutes, you can set up a support site for yourself or a loved one. You can also connect with other people who suffer from similar medical problems.

In a future blog post I will explore CarePages , a similar online space.

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What is the evidence for the 6 month sobriety rule in order to be added to a liver transplant waiting list?

calendarMost liver transplant centers impose a rule of  6 months demonstrated sobriety before they will add a potential transplant candidate to their waiting list. Since alcoholic cirrhosis is one of the most common indications for liver transplants in Western countries, it makes sense that there would be concern that transplants might not be successful due to alcoholic recidivism. On the other hand, many patients  simply cannot wait 6 months just to be added to the waiting list and there is increasing evidence that this 6 month sobriety criteria is somewhat arbitrary and not  necessarily a proven indicator.

Recent research of PubMed ( the major database of medical literature) reveals these  11 articles on this topic in recent years (abstracts provided when available).If you would like to obtain the full text of these articles or find out how I can help you use this information or find other transplant specific information for you, please use the contact form below.

1. J Med Ethics. 2006 May;32(5):263-5.

When alcohol abstinence criteria create ethical dilemmas for the liver transplant team.

Bramstedt KA, Jabbour N.

Department of Bioethics, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, JJ-60, Cleveland, OH 44195, USA. txbioethics@yahoo.com

PMCID: PMC2579412 PMID: 16648275  [PubMed – indexed for MEDLINE]

2. Ann Hepatol. 2012 Mar-Apr;11(2):213-21.

Predictive factors of abstinence in patients undergoing liver transplantation for alcoholic liver disease.

Altamirano J, Bataller R, Cardenas A, Michelena J, Freixa N, Monrás M, Ríos J, Liccioni A, Caballería J, Gual A, Lligoña A.

Liver Unit, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, CIBER de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

INTRODUCTION: Alcoholic cirrhosis is one of the most common indications for liver transplantation (LT) in western countries. A major concern about transplant patients due to alcoholic liver disease (ALD) is alcoholic recidivism. Data concerning psycho-social characteristics of patients with 6 months of abstinence at initial evaluation for LT is scarce. Objectives. The aims of this study were 1) To evaluate the psycho-social profile of a cohort of patients with alcoholic cirrhosis being evaluated for LT. 2) Determine factors associated with abstinence from alcohol at initial psycho-social evaluation for LT and 3) To evaluate the potential impact of alcohol-free beer consumption on 6-month abstinence. MATERIAL AND METHODS: Ninety patients referred to the Alcohol Unit of the Hospital Clínic of Barcelona (January 1995-December 1996) were included. Univariate and multivariate logistic regression analyses were used to identify the factors associated with cessation in alcohol consumption and with 6-month abstinence. RESULTS: Factors associated with cessation in alcohol consumption were awareness of alcohol toxicity (OR = 5.84, CI 1.31-26.11, p = 0.02) and family recognition (OR = 3.81, CI 1.27-11.41, p = 0.01). Cessation of alcohol consumption at knowledge of ALD (OR = 5.50, CI 1.52-19.81, p = 0.009), awareness of alcohol toxicity (OR = 2.99, CI 1.02-9.22, p = 0.05) and family recognition (OR = 5.21, CI 1.12-24.15, p = 0.03) were the independent factors associated with 6-month abstinence previous to psycho-social evaluation for LT. CONCLUSION: In conclusion awareness of alcohol toxicity and family recognition are the independent factors that influence cessation in alcohol consumption and 6-month abstinence in patients evaluated for LT. The use of alcohol-free beer was associated with a higher rate of abstinence in patients without alcohol cessation.

PMID: 22345338  [PubMed – indexed for MEDLINE]

3. Curr Opin Organ Transplant. 2013 Jun;18(3):259-64. doi: 10.1097/MOT.0b013e32835fb94b.

Should length of sobriety be a major determinant in liver transplant selection?

Rice JP, Lucey MR.

Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53705-2281, USA.

PURPOSE OF REVIEW: For patients with alcoholic liver disease, most liver transplant programs enforce a mandatory period of sustained abstinence prior to considering transplant. The ‘6-month’ rule may eliminate potentially acceptable transplant candidates from a lifesaving procedure. This review focuses on the use of sobriety length as a determinant of transplant candidacy and as a predictor of future alcohol use. We will also review the use of liver transplant in patients with severe alcoholic hepatitis, and the impact of alcohol use on posttransplant outcomes. RECENT FINDINGS: Patients with alcoholic hepatitis that underwent transplantation had an increased survival when compared with controls. Alcohol relapse after transplantation was infrequent. Similarly, a United Network for Organ Sharing database review revealed similar survival in patients transplanted for alcoholic hepatitis versus alcoholic cirrhosis. Allograft loss due to alcohol use was not seen. However, alcohol usage after transplantation has been associated with a lower long-term survival in both alcoholic and nonalcoholic recipients. SUMMARY: The 6-month rule is insufficient in predicting relapse risk. Liver transplantation may be lifesaving in cases of alcoholic hepatitis and inflexible sobriety rules may eliminate patients from transplant consideration at a low risk of relapse. An ongoing alcohol use assessment, both pre- and posttransplant, are critical to achieving good long-term outcomes.

PMID: 23492643  [PubMed – indexed for MEDLINE]

4. N Engl J Med. 2012 Feb 2;366(5):478-9; author reply 479. doi: 10.1056/NEJMc1114241#SA3.

Early liver transplantation for severe alcoholic hepatitis.

Di Martino V, Sheppard F, Vanlemmens C.

Erratum in     N Engl J Med. 2012 Apr 5;366(14):1356.

Comment on     N Engl J Med. 2011 Nov 10;365(19):1790-800.

PMID: 22296091  [PubMed – indexed for MEDLINE]

5. N Engl J Med. 2012 Feb 2;366(5):478; author reply 479. doi: 10.1056/NEJMc1114241#SA2.

Early liver transplantation for severe alcoholic hepatitis.

John S, Chung RT.

Comment on     N Engl J Med. 2011 Nov 10;365(19):1790-800.

PMID: 22296090  [PubMed – indexed for MEDLINE]

6. N Engl J Med. 2012 Feb 2;366(5):477-8; author reply 479. doi: 10.1056/NEJMc1114241#SA1.

Early liver transplantation for severe alcoholic hepatitis.

Tamura S, Sugawara Y, Kukudo N.

Comment on     N Engl J Med. 2011 Nov 10;365(19):1790-800.

PMID: 22296089  [PubMed – indexed for MEDLINE]

7. N Engl J Med. 2011 Nov 10;365(19):1836-8. doi: 10.1056/NEJMe1110864.

Transplantation for alcoholic hepatitis–time to rethink the 6-month “rule”.

Brown RS Jr.

Comment on     N Engl J Med. 2011 Nov 10;365(19):1790-800.

PMID: 22070481  [PubMed – indexed for MEDLINE]

8. N Engl J Med. 2011 Nov 10;365(19):1790-800. doi: 10.1056/NEJMoa1105703.

Early liver transplantation for severe alcoholic hepatitis.

Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, Castel H, Duhamel A, Pageaux GP, Leroy V, Dharancy S, Louvet A, Boleslawski E, Lucidi V, Gustot T, Francoz C, Letoublon C, Castaing D, Belghiti J, Donckier V, Pruvot FR, Duclos-Vallée JC.

Hôpital Claude Huriez, Services Maladies de l’Appareil Digestif and INSERM Unité 995, Centre Hospitalier Universitaire, de Lille and Université Nord de France, Lille.

Comment in     Z Gastroenterol. 2012 Jul;50(7):699-701.     N Engl J Med. 2011 Nov 10;365(19):1836-8.     N Engl J Med. 2012 Feb 2;366(5):478; author reply 479.     N Engl J Med. 2012 Feb 2;366(5):477-8; author reply 479.     N Engl J Med. 2012 Feb 2;366(5):478-9; author reply 479.     Gastroenterology. 2012 Apr;142(4):1037-8.     Evid Based Med. 2013 Feb;18(1):21-2.     Gastroenterol Hepatol. 2012 Aug-Sep;35(7):457-9.     J Hepatol. 2012 Aug;57(2):451-2.

BACKGROUND: A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose hepatitis is not responding to medical therapy have a 6-month survival rate of approximately 30%. Since most alcoholic hepatitis deaths occur within 2 months, early liver transplantation is attractive but controversial. METHODS: We selected patients from seven centers for early liver transplantation. The patients had no prior episodes of alcoholic hepatitis and had scores of 0.45 or higher according to the Lille model (which calculates scores ranging from 0 to 1, with a score ≥ 0.45 indicating nonresponse to medical therapy and an increased risk of death in the absence of transplantation) or rapid worsening of liver function despite medical therapy. Selected patients also had supportive family members, no severe coexisting conditions, and a commitment to alcohol abstinence. Survival was compared between patients who underwent early liver transplantation and matched patients who did not. RESULTS: In all, 26 patients with severe alcoholic hepatitis at high risk of death (median Lille score, 0.88) were selected and placed on the list for a liver transplant within a median of 13 days after nonresponse to medical therapy. Fewer than 2% of patients admitted for an episode of severe alcoholic hepatitis were selected. The centers used 2.9% of available grafts for this indication. The cumulative 6-month survival rate (±SE) was higher among patients who received early transplantation than among those who did not (77 ± 8% vs. 23 ± 8%, P<0.001). This benefit of early transplantation was maintained through 2 years of follow-up (hazard ratio, 6.08; P = 0.004). Three patients resumed drinking alcohol: one at 720 days, one at 740 days, and one at 1140 days after transplantation. CONCLUSIONS: Early liver transplantation can improve survival in patients with a first episode of severe alcoholic hepatitis not responding to medical therapy. (Funded by Société Nationale Française de Gastroentérologie.).

PMID: 22070476  [PubMed – indexed for MEDLINE]

9. Hepatogastroenterology. 2012 Mar-Apr;59(114):4 p preceding 311. doi: 10.5754/hge11691.

Alcoholic hepatitis and liver transplantation:is an abstinence of six months necessary?

Testino G, Borro P.

PMID: 22510448  [PubMed – indexed for MEDLINE]

10. Clin Liver Dis. 2012 Nov;16(4):851-63. doi: 10.1016/j.cld.2012.08.012.

Evaluation and selection of the patient with alcoholic liver disease for liver transplant.

Leong J, Im GY.

Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA. Jennifer.leong@mountsinai.org

Alcoholic liver cirrhosis is the second most common indication for liver transplantation in the United States. Studies have shown that these patients do as well as those transplanted for nonalcoholic liver disease. Recently, transplantation of patients with alcoholic liver disease has come under closer scrutiny following an article in the New England Journal of Medicine demonstrating comparable outcomes and survival in patients transplanted for acute alcoholic hepatitis. This article reviews the literature and data on the evaluation and selection of patients with alcoholic cirrhosis for liver transplant, and discusses the most recent indication (once a contraindication), acute alcoholic hepatitis.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID: 23101986  [PubMed – indexed for MEDLINE]

11. Evid Based Med. 2013 Feb;18(1):21-2. doi: 10.1136/ebmed-2012-100541. Epub 2012 Jun 26.

In patients with a first episode of severe alcoholic hepatitis non-responsive to medical therapy, early liver transplant increases 6-month survival.

Lucey MR.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA. mrl@medicine.wisc.edu

Comment on     N Engl J Med. 2011 Nov 10;365(19):1790-800.

PMID: 22736660  [PubMed]

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Some of the psychology behind resistance to signing up for organ donation

What’s organ donation got to do with Macy’s?

      When driving health behavior change, think Macy’s
Published on July 20, 2013 by Talya Miron-Shatz, Ph.D. in Baffled by Numbers       .

“I was recently honored to be an invited keynote speaker at Donate Life America’s annual national conference. As a researcher, who cares a lot about spreading the word, I do a considerable amount of public speaking. Public crying, however, is something I get to do far less often. The exception was in Indianapolis, as the Donate Life America (DLA) conference. DLA is tasked with the sacred mission of promoting organ donations, so I sat there before my talk as the mike was passed around and DLA employees from so many states introduced themselves and their connection – some were living donors, some recipients, some had family members who received a donation, and others with related to donors. I was crying, emotionally overwhelmed, knowing that, by this single talk, I could perhaps help make the biggest difference ever in my career.

How can I, a decision scientist, help motivate people sign up as potential donors? The problem with organ donation, as with other domains of behavior change, is that there is no immediate cause to action. Even if you have a positive attitude toward the topic, this does not mean you’ll necessarily act upon it.

 You would think that if people grasp the importance of organ donation – either when one passes away or through living donation – they would just sign up to do it. But this is not the case. It’s easy to demonstrate with the 2011 Earthquake in Japan. I asked that everyone who’s heard about it stand up. The entire room did. Then I asked everyone who cared about the earthquake and the suffering of the Japanese people to remain standing, which they all did. Then came the tricky part: “please remain standing only if you donated something – food, time, money – to help the earthquake victims.” As you can imagine, most people sat down. Not because they did not care, or would not have helped had they been given the opportunity, but because people need a boost, need it to be available and easy, in order to act upon their attitudes, positive as these may be. This applies to organ donation as well, and can help explain why not all of us are donors.

Perhaps counter intuitively, one issue that hampers organ donation is the fact that you can always sign up for it. Why go on Facebook and sign up today? Why not tomorrow, or next month? Next year, even? No urgency, because none of us are planning to die today.

Think of women over 50, who need to undergo routine mammograms. They might be busy, or afraid that the exam would hurt, or maybe they have the best intentions and really mean to go, but not today. There is no urgency, and when no urgency exists, execution can be indefinitely postponed. This is just like organ donation.

Wharton’s professor Katherine Milkman partnered with a life style company to promote mammograms, which women know are important to get, but never seem to have the time to. She used the advanced technology of refrigerator magnets and randomly assigned women to one of two magnet conditions. Half said “get a mammogram”, whereas the other half promoted “get a mammogram by Thanksgiving”. Yes, it’s false urgency, because the clinics are not going to run out of mammograms by Thanksgiving, and there really is not connection between radiography, turkeys and yams. But knowing that mammograms are important just does not seem to be enough to prompt action. The deadline helped women prompt themselves to action, and being assigned a deadline is apparently easier than creating one for yourself.

If you think people don’t fall for false urgency, well, think back to the last time you rushed to Kohl’s or Macy’s on a Super Saturday. One of these really rare and urgent events that happen, what, once a month? I’m sure you get it.

In another study, prof. Milkman took care of yet another important topic where motivation isn’t trivial – flu shots. She collaborated with a company that provides its employees with an online health clinic. The fact that the clinic is open year round neutralizes urgency – why get a shot today when I could go get it next week? Indeed vaccination rates were as low as 33.1%. Prof. Milkman mailed the employees a letter in 3 versions – the first was the usual invitation, the second was the same invitation, but employees were asked to write down the date when they will go to the clinic. This increase vaccination rates by 1.5%. The third version required employees to write down both the date and the time of day when they will go to the clinic. Vaccination went up by 4.2%, which may not be a lot, but is statistically significant.

Going beyond statistics, and back to organ donations: any small increase in the number of donors can help save lives, or bring a huge improvement to the lives of those receiving a cornea or tissue donation. To avoid falling into the “I’ll do it when I get a chance” trap, set a date. Decide that by your birthday, Labor Day, or even this weekend, you will sign up to be an organ donor. Anyone can be a donor, even if they’re old or unhealthy, they can still donate their corneas, So set that date, and treat it with the same sense of urgency you would treat a Macy’s Super Saturday. Do it now.  ”

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September 1, 2013 · 6:14 pm

Poll: Is it fair to accept an organ donation if you or your family isn’t willing to donate an organ?

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Noninvasive protein test can better predict kidney transplant outcomes

In a multicenter research study published in the Aug 22 2013 issue of American Journal of Transplantation, authors report that a low level of a protein called CXCL9 can rule out rejection as a cause of kidney injury. Currently, the only definitive way to distinguish rejection from other causes of kidney is to perform a biopsy. While this is generally safe, it does carry some risk for the patient and is not always accurate. “A noninvasive urine test to accurately monitor the risk of kidney rejection could dramatically reduce the need fr biopsies and possibly enable doctors to safely reduce immunosuppressive therapy in some patients” said NIAID Director Anthony S. Fauci, M.D.

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Filed under Cutting Edge Research, Kidney Transplantation, Organ Rejection